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Cushing's Syndrome

Cushing's syndrome is a condition caused by prolonged exposure to high levels of cortisol, leading to specific physical and mental changes.

Doctor reviewing endocrine disorder test results for Cushing's syndrome

Overview

Cushing's syndrome occurs when the body is exposed to high levels of the hormone cortisol for a long time. It can be caused by taking corticosteroid medications or by tumors that produce cortisol.

Illustration of the adrenal glands and cortisol pathway

Symptoms

Symptoms include rapid weight gain (especially in the face, neck, and trunk), skin that bruises easily, purple stretch marks, high blood pressure, and diabetes.

Clinical signs of Cushing's syndrome such as facial rounding and weight gain

Causes

Causes include long-term use of corticosteroid medications, and tumors in the pituitary gland or adrenal glands.

MRI scan showing a pituitary tumor as a cause of Cushing's disease

Treatment

Treatment depends on the cause and may involve reducing medication, surgery, radiation, or medications to control cortisol production.

Medications used to control cortisol production in Cushing's syndrome

When to See a Doctor

If you have symptoms of Cushing's syndrome, see a doctor.

Doctor consulting a patient about Cushing's syndrome symptoms